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Vibrating pill, ingestible sensor: mini robots tackle gut disorders

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Researchers at Caltech and MIT have developed an ingestible sensor that can be monitored as it moves through the digestive tract and tested it in pigs./AFP
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Feb 15, 2023 - 03:19 AM

WASHINGTON — A pill that vibrates to relieve constipation, a sensor that can be tracked in the gut — medical researchers are turning to tiny robots to treat or diagnose gastrointestinal disorders.

“This is a very booming field,” said Saransh Sharma, a doctoral student at the California Institute of Technology (Caltech) involved in the development of the ingestible diagnostic sensor.

“You have medical robots that are so small you can just send them inside a person using the oral passage and they can do a lot of sensing and actuation inside the gut,” Sharma told AFP.

About 16 of every 100 adults in the United States suffer from symptoms of constipation, according to the US health authorities, and the number doubles for Americans over the age of 60.

Researchers at the Massachusetts Institute of Technology (MIT) and Caltech have developed an ingestible sensor that can be monitored as it travels through the digestive tract.

The device, 20 millimeters in length and eight mm in diameter, could help physicians diagnose gastrointestinal motility disorders that prevent food from moving normally through the digestive tract.

The capsule’s location reveals where a slowdown is taking place.

“That gives the doctor a lot of the essential information to do a better job in the curing and the diagnosis and the treatment plan,” Sharma said.

The sensor could also provide an alternative to invasive procedures such as endoscopy or other diagnostic techniques such as nuclear imaging, X-rays or catheters.

It has been tested on pigs and the team behind the research hopes to eventually obtain the approval of the US Food and Drug Administration for human clinical trials.

“If we can demonstrate a device inside large animals like pigs up to a very high confidence, we can say that it will scale very well in human anatomy as well,” Sharma said.

The authors published the results of their research on Monday in the journal Nature Electronics.

They said the sensor works by detecting a magnetic field produced by an electromagnetic coil located outside of the body.

The strength of the magnetic field varies with distance from the coil and the sensor’s position within the digestive tract can be calculated to within millimeters based on measurement of the magnetic field.

Vibrating capsule 

While the ingestible sensor is still in the development phase, an Israeli company called Vibrant Gastro recently began marketing a vibrating capsule in the United States designed to relieve chronic constipation.

The drug-free Vibrant capsule is intended for constipation sufferers who have not received bowel relief after a month of laxative treatments. It has been FDA-approved.

In a Phase 3 clinical trial of 300 people, participants who took Vibrant had bowel movements significantly more frequently than those who took a placebo.

The Vibrant capsule produces gentle vibrations to stimulate the colon and increases the number and frequency of bowel movements, according to the manufacturer.

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